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Side by side

Nioxin Nioxin System 4 Scalp Therapy Conditioner vs Paul Mitchell Scalp Care Regeniplex Conditioner

85% function match · 8 of the 10 functions we compared match Formula overlap 56%. Nioxin Nioxin System 4 Scalp Therapy Conditioner and Paul Mitchell Scalp Care Regeniplex Conditioner share 4 ingredients among each other's most prominent.

Based on your consultation

Which of these fits your hair?

We check your pattern, moisture need, scalp, fragrance tolerance, weight sensitivity and more against each formula — and say which one lines up.

Your profile at a glance

  • Your answers appear here
  • Your answers appear here
  • Your answers appear here
  • Your answers appear here

When each one is the right call

What each formula is built for, from its own ingredient list.

  • Nioxin System 4 Scalp Therapy Conditioner — fragrance-free
  • Scalp Care Regeniplex Conditioner — protein-hungry hair

Side by side

Every trait, aligned

One row per trait, read from each product’s own ingredient list and record. A dash means we have not researched that field for that product — it is not a “no”.

Trait
Nioxin System 4 Scalp Therapy Conditioner — front of package Nioxin

Nioxin System 4 Scalp Therapy Conditioner

  • Conditioner
  • Salon
  • Sulfate-free
  • Fragrance-free
Paul Mitchell Scalp Care Regeniplex Conditioner — 10.14 oz container Paul Mitchell

Scalp Care Regeniplex Conditioner

  • Conditioner
  • Salon
  • Sulfate-free
Price, size & price per ounce
$26–27 10.1 oz · $2.62/oz
about $30 10.14 oz · $2.96/oz
Value / price positioning
Upper-mid price for a conditioner $$$$$ Salon tier · costs more than 68% of the 689 conditioners we’ve priced
Upper-mid price for a conditioner $$$$$ Salon tier · costs more than 73% of the 689 conditioners we’ve priced
Best for hair types
All types Nothing in the formula or the claims narrows this to one pattern. Your hair
All types Nothing in the formula or the claims narrows this to one pattern. Your hair
Moisture level Same
Low Humectants appear, but low enough to be a minor part. Your hair
Low Humectants appear, but low enough to be a minor part. Your hair
Oils and butters Same
None No oils or butters in the list. Your hair
None No oils or butters in the list. Your hair
Slip / detangling Differs
High Conditioning agents sit high in the list — this is a detangling formula. Your hair
Moderate Conditioning agents are present, lower in the list. Your hair
Weight on hair Same
Medium Middle of the range — noticeable on fine hair, light on coarse hair. Your hair
Medium Middle of the range — noticeable on fine hair, light on coarse hair. Your hair
Fragrance
None listed No fragrance is listed. Your hair
Present Fragrance is listed; it sits below the working ingredients. Your hair
Protein Differs
Minor Protein appears, low enough to be a supporting ingredient. Your hair
Prominent Protein high in the list — a strengthening formula, not a moisture one. Your hair
Silicone / wax buildup Same
High Water-insoluble silicones or waxes: a detergent wash is what removes them. Your hair
High Water-insoluble silicones or waxes: a detergent wash is what removes them. Your hair
Clarifying wash needed
High Your hair
High Your hair
Hard-water defence Same
Chelators present Chelators are present — they bind hard-water and pool minerals. Your hair
Chelators present Chelators are present — they bind hard-water and pool minerals. Your hair
Formula completeness
out of 10
Complete for its job
out of 10
Covers the core
Who should choose this
  • Fragrance-freeno fragrance (parfum) on the label — scented
  • Maximum slipfor hair that tangles the moment it is wet
  • Very dry hairno fast-drying alcohol in the list
  • Cuticle-smoothing pHa pH adjuster brings it to the acidic range hair prefers
  • Protein-hungry hairthat stretches and stays stretched when wet
  • Cuticle-smoothing pHa pH adjuster brings it to the acidic range hair prefers
  • A wide range of haira middle-of-the-range weight
Why you might skip it
  • Scents bother youthis product carries a strong scent
  • Curly-method routinesthese silicones need a detergent to remove
  • Vegan and cruelty-freeour record does not support both claims here
  • Scents bother youthis product carries a scent
  • Curly-method routinesthese silicones need a detergent to remove
  • Protein-sensitive hairthat goes stiff or straw-like on protein
from the formula stated by the brand reported by reviewers Scale: 1 dot low · 5 dots high, within this product type.
More facts about each one
Type
Conditioner
Conditioner
Line
System 4
Scalp Care Regeniplex
Where to buy
Ulta · Amazon
Manufacturer · Ulta
Free of
  • sulfate-free
  • fragrance-free
  • sulfate-free
Cruelty-free
Not cruelty-free · PETA-listed
Cruelty-free · PETA-listed
Scent
—
Mint & herbal · Fresh & airy

Facts as we recorded them. A dash means we have not researched that field for that product — it is not a "no".

The bottom line

The bottom line depends on your hair

Which of these two suits you is a question about your hair, not about them. The consultation answers it — and tells you what your routine needs around it.

Take the consultation

$49.00 once, for your consultation and hair profile. No subscription, no required purchases.

The detail behind the table

Where the readings above come from: the ingredient lists themselves, each brand’s claims checked against them, what owners report, and cost per ounce in context.

Shared and distinct ingredients

Shared and distinct ingredients

Computed from the ingredient lists as printed. "Shared" means both lists carry it; where it sits on each label is stated, because position is what tells you how much.

What both formulas carry

IngredientNioxin System 4 Scalp Therapy ConditionerScalp Care Regeniplex Conditioner
Water
Neutral
#1Leading
#1Leading
Cetyl Alcohol
Softens
#2Leading
#3Leading
Stearamidopropyl Dimethylamine
Detangles
#3Leading
#17Below the 1% line
Stearyl Alcohol
Softens
#4Supporting
#2Leading
Phenoxyethanol
Stabilizes
#6Below the 1% line
#30Below the 1% line

What only one of them carries

Nioxin System 4 Scalp Therapy Conditioner

Scalp Care Regeniplex Conditioner

Full ingredient list — Nioxin System 4 Scalp Therapy Conditioner (44)
Full ingredient list — Scalp Care Regeniplex Conditioner (43)

Claims check

What each brand says, against what each formula shows

Claims are quoted from each brand. We only mark one supported, partly supported, or conflicting when that product’s ingredient list actually speaks to it.

VerdictsNioxin System 4 Scalp Therapy ConditionerScalp Care Regeniplex Conditioner
Supported
1
0
Partly supported
0
1
Stated by brand
1
0
Potential conflict
0
0

Nioxin System 4 Scalp Therapy Conditioner

  • Thickens and strengthens hair against breakage while providing color protectionSupportedLess fade per wash.
  • 8 out of 10 users saw thicker, fuller hair in 30 daysStated by brandNot something a label can show.

Scalp Care Regeniplex Conditioner

  • Detangle fine, fragile strands and make hair look and feel stronger and thickerPartly supportedA little slip, not a lot.

What owners say

What people report

Recurring themes our researchers wrote in their own words from sourced reviews. We do not store or scrape star ratings, and we never balance one product’s themes against another’s by inventing them.

Nioxin Nioxin System 4 Scalp Therapy Conditioner draws complaints about weight and the scent; Paul Mitchell Scalp Care Regeniplex Conditioner draws complaints about tangling and volume.

Nioxin System 4 Scalp Therapy Conditioner

Pairing the conditioner/system with the brand's leave-in scalp treatment (night serum) was reported to shorten the time to noticing less shedding, down to a few days.

reviewer combining with Nioxin overnight scalp serum

Reviewers using the System 4 kit for progressed thinning report noticeably less hair fall and fine new regrowth within weeks.

multiple reviewers, several weeks of regular use

A repeated complaint is the strong fragrance of the system, described as a heavy perfume scent that some find off-putting despite good results.

reviewer using the full system regularly

Not universally effective: one reviewer with a documented thyroid condition reported the opposite of the intended effect, with more breakage and scalp dryness on weekly use.

reviewer with a self-reported thyroid condition

Scalp Care Regeniplex Conditioner

Other reviewers credit the Tea Tree Scalp Care regimen with calming an irritated/reactive scalp

scalp sensitivity/allergic-reaction concerns

A reviewer reported new scalp itching and irritation that developed only after starting the product, resolving after discontinuing use

no prior history of product sensitivities

Users with fine, thin hair report the product did not thicken hair as marketed and some felt it contributed to more shedding/thinning

fine/thin hair, post-partum hair changes

Multiple reviewers report the current formula leaves hair noticeably more tangled than an earlier version of the product

long-time users comparing to prior formulation

Price check

Cost per ounce, in context

Cost per ounce against every product of this type we have priced, each at the size it is most often sold in. Value labels are computed from that percentile and from how many products that do the same job cost less; they are comparisons, not judgements about a brand.

$2.62/oz vs $2.96/oz — within about the same cost per ounce.

$0.09/oz median $1.60/oz $56.25/oz $2.62/oz Nioxin System 4 Scalp Ther $2.96/oz Scalp Care Regeniplex Cond

Every mark sits on one distribution because these are compared against the same set: 689 conditioners with a computable unit price.

Value readNioxin System 4 Scalp Therapy ConditionerScalp Care Regeniplex Conditioner
Label
Upper-mid price for a conditionerSits in the middle of the range for conditioners per ounce.
Upper-mid price for a conditionerSits in the middle of the range for conditioners per ounce.

Computed from cost per ounce against every product of this type we have priced, and from how many products that do the same job cost less. It is a comparison, not a judgement about the brand.

Compare with something else

Close formulas to each of these, as their own comparison pages.

Nioxin System 4 Scalp Therapy Conditioner vs ORS HAIRepair Banana & Bamboo Nourishing ConditionerORS · 98% function matchScalp Care Regeniplex Conditioner vs Quenching ConditionerBumble and bumble · 96% function matchNioxin System 4 Scalp Therapy Conditioner vs Caviar Anti-Aging Infinite Color Hold ConditionerAlterna Haircare · 95% function matchScalp Care Regeniplex Conditioner vs Body Envy Volumizing ConditionerHerbal Essences · 88% function matchNioxin System 4 Scalp Therapy Conditioner vs Aura Boost Hydrate ConditionerNot Your Mother's · 95% function matchScalp Care Regeniplex Conditioner vs Clinical Dandruff Defense + Dry Scalp Rescue ConditionerHead & Shoulders · 87% function matchNioxin System 4 Scalp Therapy Conditioner vs Aura Boost Restore ConditionerNot Your Mother's · 95% function matchScalp Care Regeniplex Conditioner vs TRESemme Healthy Volume ConditionerTRESemme · 87% function match

Nioxin System 4 Scalp Therapy Conditioner · Scalp Care Regeniplex Conditioner · All conditioners in the library

How this page was made

  • This page is assembled from the same researched records the individual product pages render: identity, each ingredient list as printed, each brand's own claims, dated price observations, and review themes written in our researchers' own words. Nothing on it is written per comparison.
  • We do not rank these against each other. Which of them suits you depends on your hair, and that is what the consultation works out.
  • The formula similarity percentage is a stored, precomputed number: position-weighted overlap of the two ingredient lists blended with agreement on the attributes we derive. It measures how alike two formulas are, not how well either works.
  • The value band is a fixed label over two stored numbers: this product’s cost per ounce as a percentile of every product of this type we have priced, each at the size it is most often sold in, and how many products we score as doing the same job cost at least a quarter less per ounce.
  • The "Is this right for you?" panel reads only your own consultation answers, and it applies exactly the filters our recommendation engine applies. It is computed when you load the page and is never stored on it.
  • 9 sources were consulted across the products on this page.
  • Ingredient order tells you relative amount only above roughly 1%. Prices are observations on the dates shown and change without notice. We do not sell these products and take no placement fees.
  • This is cosmetic information, not medical advice, and nothing here diagnoses or treats a health condition.

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