Clinical Dandruff Defense + Dry Scalp Rescue Conditioner

In the US, ingredients above 1% are listed from most to least. Below 1% they can appear in any order. Each note keeps three things apart: what the ingredient generally does, its role in this type of product, and what its position can tell you.

• 1 Zinc Pyrithione · Pyrithione Zinc (0.5%)
  General function

  An over-the-counter anti-dandruff active that reduces the yeast associated with flaking. Its percentage is stated in the drug facts panel.

  Leading ingredient

  Listed in the first three ingredients, it is likely a structural part of this formula.

  PubChem
  • active
• 2 Water
  General function

  The base of almost every rinse-off and cream hair product. It carries everything else and is normally the first ingredient on the label.

  Leading ingredient

  Listed in the first three ingredients, it is likely a structural part of this formula.

  • solvent
• 3 Stearyl Alcohol
  General function

  A fatty alcohol that thickens conditioners and helps them coat the hair evenly.

  Leading ingredient

  Listed in the first three ingredients, it is likely a structural part of this formula.

  May suitDry, coarse, or high-porosity hair

  The waxy solid that gives a conditioner its body. It deposits a soft lubricating layer, which is most of what makes hair feel smooth after rinsing.

  May suitFrizz-prone, damaged, or high-friction hair

  Deposits with the cationic conditioners and helps them lie flat along the strand, which is where the detangling actually comes from.

  DependsFine or easily flattened hair

  Near the top of a conditioner it is doing most of the conditioning, and most of the weighting, at the same time.

  PubChem
  • fatty alcohol
  • emollient
  • thickener
• 4 Cetyl Alcohol
  General function

  A fatty alcohol used to thicken creams and add slip. It softens rather than dries.

  Supporting ingredient

  Listed in positions 4–8, it likely makes a meaningful contribution alongside the formula's main ingredients.

  May suitDry, coarse, or high-porosity hair

  The waxy solid that gives a conditioner its body. It deposits a soft lubricating layer, which is most of what makes hair feel smooth after rinsing.

  May suitFrizz-prone, damaged, or high-friction hair

  Deposits with the cationic conditioners and helps them lie flat along the strand, which is where the detangling actually comes from.

  DependsFine or easily flattened hair

  Near the top of a conditioner it is doing most of the conditioning, and most of the weighting, at the same time.

  PubChem
  • fatty alcohol
  • emollient
  • thickener
• 5 Stearamidopropyl Dimethylamine
  General function

  A gentle conditioning agent activated by the acid in the formula. It smooths the cuticle without much build-up.

  Supporting ingredient

  Listed in positions 4–8, it likely makes a meaningful contribution alongside the formula's main ingredients.

  May suitFrizz-prone, damaged, or high-friction hair

  A cationic conditioning agent: it binds to the damaged, negatively charged parts of the cuticle and lowers combing friction there.

  May suitVery dry or highly damaged hair

  The class that does the detangling in a conditioner. It deposits lubrication where the cuticle is worn.

  DependsBuild-up-sensitive routines

  Substantive by design. A routine with no detergent wash gives it nothing to leave with.

  PubChem
  • conditioning agent
• ▾Below about here, the order stops meaning much. These are usually used at 1% or less.
• 6 Glutamic Acid
  General function

  An amino acid used for moisture binding and to bring the formula to an acidic pH.

  Estimated lower-concentration zone

  It appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.

  May suitVery dry or highly damaged hair

  Amino acids are the smallest protein fraction and bind water as well, so they add far less stiffness than a hydrolysed protein does.

  DependsFrizz-prone, damaged, or high-friction hair

  pH adjusters are how a formula is brought to a chosen acidity, and an acidic formula keeps the cuticle lying flatter than an alkaline one. Which way this one moves the pH depends on the formula, and the finished pH is not on the label.

  DependsProtein-sensitive hair

  The lightest option in the protein family, but still protein — worth watching if protein reliably stiffens your hair.

  PubChem
  • amino acid
  • pH adjuster
• 7 Dimethicone
  General function

  The most common conditioning silicone. It coats the strand for shine, slip, and frizz control, and needs a detergent (not just water) to wash out.

  Estimated lower-concentration zone

  It appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.

  May suitClimate-sensitive or frizz-prone hair

  A surface film slows how quickly humidity reaches the cortex, which is what limits swelling-driven frizz in damp air.

  May suitFrizz-prone, damaged, or high-friction hair

  Lays a smooth film along the cuticle, which lowers combing friction and flattens the surface irregularities that read as frizz.

  • silicone
  • emollient
  • conditioning agent
• 8 Fragrance
  General function

  An undisclosed blend of scent ingredients. Regulations let it stay unlisted, so a fragrance-free product is the only way to be certain what is not in it.

  Estimated lower-concentration zone

  It appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.

  May not suitFragrance-sensitive routines

  Declared fragrance. On a fragrance-sensitive routine this is the line that decides it, wherever it sits on the label.

  • fragrance
  • declared fragrance
• 9 Phenoxyethanol
  • preservative
• 10 Benzyl Alcohol
  • preservative
  • solvent
• 11 Sodium Chloride
  • salt
  • thickener
• 12 Citric Acid
  General function

  Used to bring the product to a slightly acidic pH, which helps the cuticle lie flat. It is almost always near the end of the list.

  Estimated lower-concentration zone

  It appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.

  May suitBuild-up-sensitive routines

  Holds hard-water minerals in solution so they rinse away instead of depositing on the hair.

  May suitFrizz-prone, damaged, or high-friction hair

  The acid side of pH adjustment, and the reason it matters is measured: alkaline formulas raise the fibre's surface negative charge, increase friction between strands and lift the scales, while lower-pH ones do the reverse.

  May suitGray, silver, or brass-prone hair

  Where a warm cast comes from water minerals rather than from the hair itself, holding those metals in solution is what removes it.

  International Journal of Trichology
  • pH adjuster
  • hard-water chelator
• 13 Honey · Honey Extract
  General function

  A natural sugar-based humectant that holds water against the strand.

  Estimated lower-concentration zone

  It appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.

  May suitFine or easily flattened hair

  Hydration with no oil attached, so it adds very little weight even high on a list.

  May suitVery dry or highly damaged hair

  Aloe is mostly water carrying sugars that bind more of it, which is why it turns up as the base of moisture-first formulas.

  DependsClimate-sensitive or frizz-prone hair

  A humectant follows the air: it holds water in humid conditions and can give it up in very dry ones. Climate decides what it does more than the label does.

  • humectant
  • botanical extract
• 14 Methylchloroisothiazolinone
  • isothiazolinone
  • preservative
• 15 Methylisothiazolinone
  • isothiazolinone
  • preservative

What the whole list adds up to

• 4 preservatives
• 3 emollients
• 3 thickeners
• 2 solvents
• 2 fatty alcohols
• 2 pH adjusters
• 2 isothiazolinones
• 1 active
• 1 conditioning agent
• 1 amino acid
• 1 silicone
• 1 conditioning agent
• 1 fragrance
• 1 declared fragrance

Drug facts actives

• Pyrithione Zinc 0.5%

This product is an over-the-counter drug as well as a cosmetic. It treats a cosmetic scalp condition; it does not diagnose or treat disease.

Ingredient list captured 2026-09-06. Formulas change, so check the package in your hand when an ingredient matters to you.