Free of sulfates, parabens, and silicones.
No sulfate detergents appear in the ingredient list.
—
Supported
Gentler on colour and coils.
Sizes & containers
8.12 fl oz (240 ml) · Usually $23–$29
Nioxin
Pro Clinical Age Defense Conditioner
Conditioner / Everyday rinse-out, detangling
- Conditioner
- Sulfate-free
- Silicone-free
- Protein-free
- Not cruelty-free · PETA-listed
Size8.12 fl oz (240 ml)usual store size · 4 sizes
Price$23–29commonly seen · 8.12 oz
Price / oz$3.26/ozat 8.12 oz
Where to buy5 stores · $19.59–29.90
Add it to your products. We’ll tell you if it’s ever recalled.
Scent:
The ingredient list declares fragrance. What it smells of is not stated, and we do not guess.
Strength: Strong
Manufacturer page: nioxin.com
Personal fit
Is this right for you?
Complete the consultation to see how well this product fits your hair and your goals. With 6,000+ products in our library, we can match you to the right ones.
- About 20 minutes, and your answers save as you go.
- Every product matched against your hair across the 22 factors we check.
- A personalized routine built around your schedule, styling habits, and local weather.
- Find products that do the same job at a lower cost.
- Your goals, scalp, damage history, water, budget, and scent preferences all shape your plan.
$49 with 60 days of follow-up questions and plan updates
$99 with 12 months. Pay once; the year renews only if you choose.
Factor
Your profile
Fit
Best for hair types
All types
Not in your profile
Moisture level
High
Not in your profile
Oils and butters
None
Not in your profile
Slip / detangling
High
Not in your profile
Weight on hair
Medium
Not in your profile
Fragrance
Prominent
Not in your profile
Protein
None
Not in your profile
Silicone / wax buildup
None
Not in your profile
Clarifying wash needed
Moderate
Not in your profile
Scent
ScentedStrong strength
Not in your profile
Show all 22 factors we check
The rest of what your plan weighs on this product.
Parabens / preservatives
None of these listed
Not in your profile
Essential oils
Present
Not in your profile
Fast-drying alcohol
None
Not in your profile
Vegan / cruelty-free
Not cruelty-free · PETA-listed
Not in your profile
Animal-derived ingredients
Not yet verified
Not in your profile
Heavy humectants
Heavy
Not in your profile
Hard-water defence
High
Not in your profile
UV filter
None listed
Not in your profile
pH adjusted
Adjusted
Not in your profile
Ingredient list
18 ingredientsAbout average
Not in your profile
Price tier
Salon
Not in your profile
Where to buy it
Brand website · Salons +1Widely sold
Not in your profile
The consultation builds your hair profile, checks every factor in this table against it, and tells you where this product fits or what to use instead.
Start your consultation$49 once, with 60 days of follow-up questions and plan updates. Nothing renews, and you never have to buy a product.
Your avoid-list
Upper-mid price for a conditioner
$3.26/oz at 8.12 oz, more than 74% of the 1119 conditioners , which mostly run $0.94–3.41/oz. The cost less.
Great for
Protein-sensitive hairthat stiffens when protein is added
Maximum slipfor hair that tangles the moment it is wet
Dry, thirsty hairhumectants and emollients both sit up front
Curly-method routinesno sulfates and no water-insoluble silicones
Silicone-free routinesno silicones appear in the list
Very dry hairno fast-drying alcohol in the list
Maybe skip if
this product has a strong scent
Hair that needs proteinthere is none in this list
Dry or very humid airwhere heavy humectants work against you
Vegan and cruelty-freeour record does not support both claims here
Tight budgetsit sits in the upper price tiers
What the formula actually does
Read from the label, not the marketing
Each row says where it comes from: F means we derived it from this product’s own ingredient list, S means it is a claim the brand makes that the formula neither confirms nor contradicts.
Slip and detangling
High
Conditioning agents sit high in the list, so this is a detangling formula.
Oils and butters
None
No oils or butters in the list.
Weight on the hair
Medium
Middle of the range: noticeable on fine hair, light on coarse hair.
Water-binding (humectants)
High
Humectants near the top: binding water is one of its main jobs.
Protein
None
No protein or amino acids in the list.
Needs detergent to remove
No
Nothing here needs a detergent wash to remove.
Hard-water defence
Chelators present
Contains chelators, which bind hard-water and pool minerals.
Fragrance
Prominent
Fragrance is in the first eight ingredients, so it makes up a larger share of the formula.
from the formula
stated by the brand
reported by reviewers
Scale: 1 dot low · 5 dots high, within this product type.
Ingredients that matter
The ingredients that change a decision
The workhorse ingredients, plus anything lower down that changes a decision. The chips name what an ingredient does. They are not safety scores, and no ingredient here is rated good or bad on its own.
| Ingredient | What it does | Why it matters | Chip |
|---|---|---|---|
| WaterAqua/Water/Eau | solvent | The base everything else is dissolved in | Neutral |
| Stearyl Alcohol | fatty alcohol | Thickens and conditions (not a drying alcohol) | Softens |
| Cetyl Alcohol | fatty alcohol | Thickens and conditions (not a drying alcohol) | Softens |
| Glycerin | humectant | Pulls water into the hair | Moisturizes |
| Stearamidopropyl Dimethylamine | conditioning agent | Conditions and softens so hair combs through | Detangles |
| Caffeine | active | The over-the-counter active | Active |
| FragranceParfum/Fragrance | fragrance | The scent | Fragrance |
| Phenoxyethanol | preservative | Keeps the product from spoiling | Stabilizes |
| Mentha Piperita (Peppermint) OilMentha Piperita Oil | botanical extract | A trace plant extract | Fragrance |
| Menthol | fragrance | The scent | Fragrance |
| Mentha Arvensis Leaf Oil | fragrance | The scent | Fragrance |
What the list leaves out, and what it carriesThe list carries no sulfates, silicones, or drying alcohols. No protein: a moisture formula, not a repair one. Fragrance is on the label. Hard-water chelators are present.
Full ingredient list (18)
In the US, ingredients above 1% are listed from most to least. Below 1% they can appear in any order. Each note keeps three things apart: what the ingredient generally does, its role in this type of product, and what its position can tell you.
-
1
Water
· Aqua/Water/Eau
General function
The base of almost every rinse-off and cream hair product. It carries everything else and is normally the first ingredient on the label.
Leading ingredientListed in the first three ingredients, it is likely a structural part of this formula.
- solvent
-
2
Stearyl Alcohol
General function
A fatty alcohol that thickens conditioners and helps them coat the hair evenly.
Leading ingredientListed in the first three ingredients, it is likely a structural part of this formula.
PubChemMay suitDry, coarse, or high-porosity hairThe waxy solid that gives a conditioner its body. It deposits a soft lubricating layer, which is most of what makes hair feel smooth after rinsing.
May suitFrizz-prone, damaged, or high-friction hairDeposits with the cationic conditioners and helps them lie flat along the strand, which is where the detangling actually comes from.
DependsFine or easily flattened hairNear the top of a conditioner it is doing most of the conditioning, and most of the weighting, at the same time.
- fatty alcohol
- emollient
- thickener
-
3
Cetyl Alcohol
General function
A fatty alcohol used to thicken creams and add slip. It softens rather than dries.
Leading ingredientListed in the first three ingredients, it is likely a structural part of this formula.
PubChemMay suitDry, coarse, or high-porosity hairThe waxy solid that gives a conditioner its body. It deposits a soft lubricating layer, which is most of what makes hair feel smooth after rinsing.
May suitFrizz-prone, damaged, or high-friction hairDeposits with the cationic conditioners and helps them lie flat along the strand, which is where the detangling actually comes from.
DependsFine or easily flattened hairNear the top of a conditioner it is doing most of the conditioning, and most of the weighting, at the same time.
- fatty alcohol
- emollient
- thickener
-
4
Glycerin
General function
Glycerin, also called glycerol, attracts moisture and mixes completely with water.
Supporting ingredientListed in positions 4–8, it likely makes a meaningful contribution alongside the formula's main ingredients.
Scientific ReportsMay suitDry, coarse, or high-porosity hairHigh-porosity hair loses water fast; a humectant holds some of it in place for longer than the wash itself would.
May suitVery dry or highly damaged hairBinds water into the outer layers of the strand, and water is what makes dry hair flexible again rather than brittle.
DependsClimate-sensitive or frizz-prone hairWater moves both ways. Measured across concentrations, glycerin solutions give water up in some conditions and take it from the air in others. What it does for you depends on how much of it is there and on the air around it.
- humectant
-
5
Stearamidopropyl Dimethylamine
General function
A gentle conditioning agent activated by the acid in the formula. It smooths the cuticle without much build-up.
Supporting ingredientListed in positions 4–8, it likely makes a meaningful contribution alongside the formula's main ingredients.
PubChemMay suitFrizz-prone, damaged, or high-friction hairA cationic conditioning agent: it binds to the damaged, negatively charged parts of the cuticle and lowers combing friction there.
May suitVery dry or highly damaged hairThe class that does the detangling in a conditioner. It deposits lubrication where the cuticle is worn.
DependsBuild-up-sensitive routinesSubstantive by design. A routine with no detergent wash gives it nothing to leave with.
- conditioning agent
-
6
Caffeine
General function
Included in scalp and thickening products for label appeal. Evidence for applied caffeine changing hair growth is limited.
Supporting ingredientPubChemListed in positions 4–8, it likely makes a meaningful contribution alongside the formula's main ingredients.
- active
- ▾Below about here, the order stops meaning much. These are usually used at 1% or less.
-
7
Fragrance
· Parfum/Fragrance
General function
An undisclosed blend of scent ingredients. Regulations let it stay unlisted, so a fragrance-free product is the only way to be certain what is not in it.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
May not suitFragrance-sensitive routinesDeclared fragrance. On a fragrance-sensitive routine this is the line that decides it, wherever it sits on the label.
- fragrance
- declared fragrance
-
8
Phenoxyethanol
General function
The most common modern preservative; it keeps the product free of bacteria and mould. It sits well below 1% of the formula.
Estimated lower-concentration zonePubChemIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
- preservative
-
9
Dicetyldimonium Chloride
General function
A conditioning agent used for slip in thick creams and masks.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
PubChemMay suitFrizz-prone, damaged, or high-friction hairA cationic conditioning agent: it binds to the damaged, negatively charged parts of the cuticle and lowers combing friction there.
May suitVery dry or highly damaged hairThe class that does the detangling in a conditioner. It deposits lubrication where the cuticle is worn.
DependsBuild-up-sensitive routinesSubstantive by design. A routine with no detergent wash gives it nothing to leave with.
- conditioning agent
-
10
Glutamic Acid
General function
An amino acid used for moisture binding and to bring the formula to an acidic pH.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
PubChemMay suitVery dry or highly damaged hairAmino acids are the smallest protein fraction and bind water as well, so they add far less stiffness than a hydrolysed protein does.
DependsFrizz-prone, damaged, or high-friction hairpH adjusters are how a formula is brought to a chosen acidity, and an acidic formula keeps the cuticle lying flatter than an alkaline one. Which way this one moves the pH depends on the formula, and the finished pH is not on the label.
DependsProtein-sensitive hairThe lightest option in the protein family, but still protein — worth watching if protein reliably stiffens your hair.
- amino acid
- pH adjuster
-
11
Niacinamide
General function
Vitamin B3, used in scalp products for conditioning claims.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
PubChemMay suitFrizz-prone, damaged, or high-friction hairDeposits a lubricating layer that makes combing easier, which is most of what stops mechanical damage adding to frizz.
- vitamin
- conditioning agent
-
12
Propylene Glycol
General function
A small humectant and solvent that keeps formulas stable and helps active ingredients spread.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
PubChemMay suitFine or easily flattened hairLight and water-binding rather than oily, so it adds less weight than oils or butters do.
May suitVery dry or highly damaged hairA small water-binding solvent. It holds moisture and helps the rest of the formula spread evenly over the strand.
DependsClimate-sensitive or frizz-prone hairA humectant follows the air: it holds water in humid conditions and can give it up in very dry ones. Climate decides what it does more than the label does.
- humectant
- solvent
-
13
EDTA
General function
Binds hard-water metals so they cannot dull hair or destabilise the formula.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
May suitBuild-up-sensitive routinesBinds the calcium and magnesium in hard water, which is what stops mineral deposits accumulating on the strand wash after wash.
May suitGray, silver, or brass-prone hairCopper and iron carried in tap water deposit on the strand and read as a dull, warm cast on gray or light hair. A chelator holds those metals in solution so the wash carries them off.
- hard-water chelator
-
14
Sodium Hyaluronate
General function
A large water-binding molecule that sits on the surface holding moisture.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
May suitDry, coarse, or high-porosity hairHigh-porosity hair loses water fast; a humectant holds some of it in place for longer than the wash itself would.
May suitVery dry or highly damaged hairBinds water into the outer layers of the strand, and water is what makes dry hair flexible again rather than brittle.
DependsClimate-sensitive or frizz-prone hairA humectant moves water in whichever direction the air allows: it holds moisture in humid conditions and can pull it back out of hair in very dry ones.
- humectant
-
15
Mentha Piperita (Peppermint) Oil
· Mentha Piperita Oil
General function
Peppermint essential oil, used for scent and the cooling feeling on the scalp.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
May not suitFragrance-sensitive routinesEssential oils are fragrance. Several carry constituents on the EU list of declared fragrance allergens, so a label with no fragrance line can still be a scented product.
- botanical extract
- essential oil
- fragrance
-
16
Menthol
General function
Produces the cooling, tingling feeling on the scalp. The sensation is real; it is not evidence that anything else is happening.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
PubChemMay not suitFragrance-sensitive routinesDeclared fragrance. On a fragrance-sensitive routine this is the line that decides it, wherever it sits on the label.
- fragrance
- active
-
17
Sodium Chloride
- salt
- thickener
-
18
Mentha Arvensis Leaf Oil
General function
Cornmint oil, used for a cooling sensation and mint scent.
Estimated lower-concentration zoneIt appears around or below the estimated 1% line, where label order no longer indicates relative amount; its role may be minor or technical.
May not suitFragrance-sensitive routinesDeclared fragrance. On a fragrance-sensitive routine this is the line that decides it, wherever it sits on the label.
- fragrance
- botanical extract
What the whole list adds up to
- 4 fragrances
- 3 thickeners
- 3 humectants
- 2 solvents
- 2 fatty alcohols
- 2 emollients
- 2 conditioning agents
- 2 actives
- 2 botanical extracts
- 1 declared fragrance
- 1 preservative
- 1 amino acid
- 1 pH adjuster
- 1 vitamin
Ingredient list captured 2026-09-11. Formulas change, so check the package in your hand when an ingredient matters to you.
Price · 8.12 oz
Commonly seen
$23–29
Good value under
$12
Priced above the products that do the same job. Stores sell it above the $12 line; products that do this job typically go for about $18 at this size.
Show the price ladder
Where we’ve seen it5 listings · 5 stores
-
Glamot.com
$19.598.12 oz · $2.41/ozSep 11Lowest per oz
-
PerfumesClub US
$23.888.12 oz · $2.94/ozSep 11Sale · was $35.10
-
Amazon
$29.008.12 oz · $3.57/ozSep 13
-
Nioxin (nioxin.com)
$29.008.12 oz · $3.57/ozSep 11
-
Care to Beauty
$29.908.12 oz · $3.68/ozSep 11
Sorted by price per ounce. Dated observations from our research, not live prices. Direct store pages, no affiliate links. We don’t sell this product.
How we work this out
- 8.12 oz is the size stores list most often; every comparison on this page is made at it. Other sizes are shown in the Sizes row and the store list.
- Commonly seen is the middle half of current prices for the 8.12 oz at recognised stores. We leave out the cheapest and most expensive quarters, so one sale or one overpriced listing can’t move it.
- Good value under $12 comes from the 8 products we score as doing the same job as this one. A quarter of them cost less than $1.44/oz; at 8.12 oz that is $12. Under that line you are paying less than most of them.
- About $18 is what those same products typically cost at this size: the midpoint of their prices per ounce, scaled to 8.12 oz.
Formula
9
Formula score
9 of 10
A complete formula at an ordinary price: mid-range per ounce among conditioners, with the working systems in place.
How the score is counted
- 6 products that do the same job cost less per ounce
- Costs more per ounce than 74% of the 1119 conditioners we’ve priced
- Covers 5 of the 6 things a conditioner should do
- Salon tier, sold at Brand website and Salons
- Conditioning agents up frontWhat makes wet hair comb through.3 pts
- Oils or butters in the working zoneSoftens the strand rather than just coating it.2 pts
- Slip for detanglingReduces the force it takes to comb wet hair.2 pts
- A humectantBinds water into the hair.1 pt
- A pH adjusterBrings the formula to the acidic pH hair prefers.1 pt
- Fragrance kept out of the top eightScent as a finishing touch, not a major share.1 pt
The formula score measures completeness for the job: a weighted share of the systems this product type is usually built around that we find in this list. It does not rate how well the product works or its quality, and it never compares across product types.
Does the same job, for less
Formulas that do the same things (cleanse, condition, coat or hold) for less per ounce. Scent, texture and where you buy them can still differ.
PanteneLowest cost per oz
Abundant & Strong Conditioner
$1.29/oz $1.97/oz less
- Protein-free
- Curly method
- Silicone-free
- Differs
Curl KeeperSame function
Big Energy - Volumizing Conditioner
$2.42/oz $0.84/oz less
- Protein-free
- Curly method
- Silicone-free
- Differs
Curl KeeperSame function
Curl Clouds - Calming Conditioner
$2.33/oz $0.93/oz less
- Protein-free
- Curly method
- Silicone-free
- Differs
See more alternatives in the product library
These products do a similar job. We haven’t matched them to you. Find the one that fits your hair, routine and budget
Final decision
Should you buy it?
A solid pick for the hair it suitsBest user
Hair that stiffens on protein, for a protein-free formula and real detangling slip
Biggest tradeoff
Not ideal for anyone sensitive to fragrance, soft, over-stretchy hair that needs protein, or very dry or very humid climates
Best alternative if not
Pantene Abundant & Strong Conditioner for similar results at a lower price
We do not sell products or take placement fees. This page states what the formula and the prices show; the consultation is what matches it to a person.
Claims check
What the brand says, and what the formula shows
Claims are quoted from the brand. We mark a claim supported, partly supported or conflicting only when the ingredient list speaks to it. Everything else stays "stated by the brand". That isn’t a criticism: most claims can’t be checked from a label.
1
SupportedBacked by ingredients
0
Partly supportedSome supporting logic
0
Stated by brandNo clear evidence
0
Potential conflictFormula works against claim
How to read this
We look at the first 10–15 ingredients and what they do in a formula, not at the marketing. If the list doesn't speak to a claim, we don't assume.
Reviewers
What people report
Themes that come up again and again in sourced reviews, written by our researchers in their own words. We don’t store or scrape star ratings.
Users with fine or thin hair describe soft, shiny results without their usual conditioner weigh-down.
Five exact Age Defense Conditioner US brand-site reviews; mixed and low-rating pass inspected.The fragrance is noticeable; users who dislike strong scents may find it too much.
Five exact Age Defense Conditioner US brand-site reviews; mixed and low-rating pass inspected.One reviewer reports softer, hydrated hair without noticing changes in thinning or gray hair.
Five exact Age Defense Conditioner US brand-site reviews; mixed and low-rating pass inspected. This particular limitation appears in one of the five reviews.More from Nioxin
How this page was made
- Everything above comes from our researched product record: identity, the ingredient list as printed, the brand's own claims, dated prices and review themes our researchers wrote in their own words. No part of this page is written by hand for one product.
- The value band is a fixed label over two stored numbers: this product’s cost per ounce as a percentile of every product of this type we have priced, each at the size it is most often sold in, and how many products we score as doing the same job cost at least a quarter less per ounce.
- Both scores out of ten are defined on this page. The formula score is completeness for the job, computed from a fixed per-format checklist shown beneath the gauge; the price score is cost per ounce against every product of this type we have priced.
- The "Is this right for you?" panel reads only your own consultation answers, and it applies exactly the filters our recommendation engine applies. It is computed when you load the page and is never stored on it.
- 7 sources consulted for this product (0 manufacturer or regulatory, 3 retailer, 4 editorial), last checked 2026-09-13.
- Ingredient references are linked for 9 of 14 product-aware annotations on this page. Fit notes are general formulation guidance. They aren’t a verdict on the finished product or on you.
- We haven’t tested this product in a lab, and we don’t physically test your hair. Formula readings come from the ingredient list. Claims about how it behaves are labelled as the brand's.
- Ingredient order tells you relative amount only above roughly 1%. Prices are what we saw on the dates shown and can change.
- Ingredient names link to our ingredient library, where each entry shows what it does, which product types use it, and where it usually sits on a label across everything we have researched.
- This is cosmetic information, not medical advice, and nothing here diagnoses or treats a health condition.
- Formula readings: derivation v23. Record last updated 2026-10-03.
